What Is Endometriosis? Endometriosis is a long-term condition in which tissue similar to the lining of the uterus grows outside the womb. These tissue deposits can occur on the ovaries, fallopian tubes, pelvic lining, bowel, bladder and, in some cases, other areas of the body. Like the lining of the uterus, these deposits respond to hormonal changes during the menstrual cycle. However, because the blood and inflammatory tissue cannot leave the body normally, this can lead to: • Chronic inflammation • Scar tissue (adhesions) • Ovarian cysts (endometriomas) • Pelvic pain • Fertility problems • Reduced quality of life It is estimated that around one in ten women of reproductive age are affected by endometriosis. Why Is Endometriosis So Difficult to Diagnose? Despite being a common condition, endometriosis frequently remains undiagnosed for many years. Common reasons include: • Symptoms overlap with other medical conditions. • Severity of symptoms varies greatly between individuals. • Routine blood tests are usually normal. • Ultrasound scans may not detect superficial disease. • MRI is helpful in selected cases but does not identify all forms of endometriosis. • Historically, confirmation often required laparoscopic surgery. As a result, many women experience years of uncertainty before receiving a diagnosis. Introducing the ZIWIG ENDOTEST® The ZIWIG ENDOTEST® is the first clinically validated saliva-based molecular test designed to support the diagnosis of endometriosis without surgery. Using advanced RNA sequencing and artificial intelligence, the test analyses hundreds of salivary microRNAs simultaneously to identify a molecular pattern associated with endometriosis. This innovative technology provides healthcare professionals with additional diagnostic information to support clinical decision-making. How Does the Test Work? The process has been designed to be simple, convenient and completely non-invasive. Step 1 – Order Online Purchase your kit securely through Repose Healthcare. Step 2 – Medical Authorisation The ZIWIG ENDOTEST® is available only following authorisation by a qualified medical professional to ensure that the test is appropriate for your clinical circumstances. Step 3 – Collect Your Sample Collect your saliva sample at home using the detailed instructions included in your kit. Step 4 – Return Your Sample Place your sample in the prepaid return packaging and post it back to the laboratory. Step 5 – Advanced Laboratory Analysis Your sample undergoes sophisticated RNA sequencing and AI-driven bioinformatic analysis in accredited specialist laboratories. Step 6 – Receive Your Results Once testing is complete, your results will be made available securely, enabling discussion with your GP or gynaecologist. Clinical Technology Behind the Test The ZIWIG ENDOTEST® uses: • High-throughput RNA sequencing • Artificial intelligence algorithms • Salivary microRNA biomarker analysis • Molecular signature recognition • Clinically validated bioinformatics Rather than looking for a single biomarker, the system evaluates a complex molecular signature associated with endometriosis, improving diagnostic performance. Clinical Evidence Clinical studies have demonstrated that the ZIWIG ENDOTEST® has high sensitivity and specificity for detecting endometriosis across different stages of the disease. The test functions as a rule-in diagnostic aid, meaning: • A positive result provides strong evidence supporting the presence of endometriosis. • A negative result reduces the likelihood of endometriosis but does not completely exclude the condition. Results should always be interpreted alongside your symptoms, medical history and any imaging or specialist assessment. Key Benefits • Non-invasive saliva collection • No surgery required • No blood sample required • Home sample collection • Clinically validated technology • Artificial intelligence-assisted molecular analysis • Earlier diagnostic support • Reduced diagnostic uncertainty • Confidential UK service • Accredited laboratory testing • Medical professional authorisation Who Is This Test Suitable For? The ZIWIG ENDOTEST® may be suitable if you: • Are a woman aged 18–43 years • Experience symptoms suggestive of endometriosis • Have chronic pelvic pain • Experience painful periods • Have pain during sexual intercourse • Have fertility concerns • Have ongoing pelvic symptoms despite previous investigations • Wish to obtain additional diagnostic information before specialist referral Contraindications and Important Information The test should not be performed if you: • Are currently pregnant. • Have a history of cancer. • Have a history of HIV infection. • Have an active bacterial or viral infection at the time of saliva collection. These conditions may affect salivary microRNA expression and reduce the reliability of the test. Sample Collection Requirements For the most accurate results, your saliva sample should not be contaminated by: • Blood from bleeding gums • Food residues • Drinks • Toothpaste • Mouthwash • Lipstick • Tobacco products • Chewing gum • Excess nasal or throat secretions Please carefully follow the sample collection instructions included with your kit. Hormonal Medication and Menstrual Cycle One of the advantages of the ZIWIG ENDOTEST® is its flexibility. You do not need to stop: • Combined oral contraceptive pills • Progesterone-only pills • Hormonal coils (IUS) • Hormone replacement therapy (HRT) • Contraceptive implants • Other prescribed hormonal medications The saliva sample can be collected at any stage of your menstrual cycle. Fertility Treatment Being investigated for infertility or undergoing assisted reproductive treatment is not a contraindication to the ZIWIG ENDOTEST®. However: • The test should not be performed during pregnancy. • If you are currently undergoing IVF or fertility treatment, you should discuss the most appropriate timing of testing with your fertility specialist. Understanding Your Results Positive Result A positive result indicates that the molecular signature detected is consistent with endometriosis. This supports referral to an appropriate healthcare professional for further assessment, imaging or treatment planning. Negative Result A negative result means that the molecular signature associated with endometriosis was not detected. However, no diagnostic test is perfect. A negative result does not completely exclude endometriosis, particularly in early or less typical disease. Why Choose Repose Healthcare? Repose Healthcare is committed to delivering evidence-based diagnostic testing supported by accredited laboratories and high clinical standards. When you choose Repose Healthcare you benefit from: • Trusted UK healthcare provider • Discreet home delivery • Confidential service • Accredited laboratory testing • Secure online ordering • UK GDPR compliance • Dedicated customer support • Reliable turnaround times • Clear laboratory reporting – Results available in 5 weeks

Frequently Asked Questions

Is the ZIWIG ENDOTEST® available throughout the UK?

Yes. We offer UK-wide delivery.

Can I collect the sample at home?

Yes. The saliva sample is collected entirely at home.

Do I need to stop taking my contraceptive pill?

No. Hormonal contraception does not need to be stopped before testing.

Does it matter where I am in my menstrual cycle?

No. The sample may be collected at any stage of your menstrual cycle.

Is pregnancy a contraindication?

Yes. The test should not be performed during pregnancy.

Can I take the test if I have a cold or COVID-19?

No. You should wait until you have fully recovered from any active infection before collecting your saliva sample.

Can I take the test while undergoing IVF?

Usually yes, provided you are not pregnant. If you are unsure, discuss the timing with your fertility specialist.

Does a positive result mean I definitely have endometriosis?

A positive result strongly supports the presence of endometriosis, but the result should always be interpreted by your healthcare professional alongside your symptoms, examination findings and any imaging studies.

Does a negative result rule out endometriosis?

No. Although a negative result reduces the likelihood of endometriosis, it does not completely exclude the condition. Order Your ZIWIG ENDOTEST® Today If you are experiencing symptoms suggestive of endometriosis, the ZIWIG ENDOTEST® offers a clinically validated, non-invasive way to support earlier diagnosis and informed clinical decision-making. Available through Repose Healthcare, this innovative saliva-based test combines cutting-edge molecular diagnostics with artificial intelligence to help you take an active role in your reproductive health. If you have any questions about your eligibility or whether the ZIWIG ENDOTEST® is appropriate for your circumstances, our team will be pleased to assist before you place your order.